NIOMESN55ثOverview

0.002231 τ

NIOME

ث (Theh)SN55

NIOME is a decentralized AI subnet that enables privacy-safe genomic intelligence by replacing real human genomes with high-fidelity synthetic genomic profiles

5GeWU…MpDq

ث / τ

0.002231 τ

−0.55%24h−13.39%7d

ث / τ Price

0.002231 τ

−0.55%24h−13.39%7d

Epoch

Epoch223/36027:24

Holders

1,786

38.17%

—

2.07%perpetual

Pool depth & trades

What moved the price

The alpha price in τ, day by day, and what moved it each way.

Log change over the last 30 days +1.65%: protocol buys 0.00%, root sells −0.57%, users net −11.00%, cross-subnet +13.22%, unattributed −0.01%.

Protocol buy
User buy (staking)
Cross-subnet
Root sell (dividend claims)
User sell (unstaking)
Residual
Price path
Market candle

About this chart

The chart follows the alpha price in τ. Each period starts at its opening price and steps through the mechanisms below, in a fixed order, to its closing price: a step that rises pushed the price up, one that falls pushed it down, and its height is how far it moved the price. A thin line carries each close into the next period’s open; it is dashed where the two differ. The faint candle behind each period is the market’s own open, high, low and close, for context.

With many periods on screen (90 days, or hours), the steps would be too thin to read, so the chart draws the price as a line instead and colours each period by the mechanism that moved it most. Hover a period for the full step-by-step breakdown.

Protocol buy: The chain spending excess emission TAO to buy alpha from the pool. A permanent protocol buyback; it pushes the price up.
Root sell: Root-dividend claims sold into the pool; they push the price down.
User buy / sell: Staking into and unstaking from this subnet.
Cross-subnet: Swaps from other subnets routed through this pool.
Residual: What the decomposition cannot attribute to a mechanism. It is always shown, never folded into another part.

Not here, because they do not move the spot price: the per-block TAO injection into the pool, and burns.

All figures are log changes, not simple percentage changes, so the parts add up exactly to the total; on big moves the two differ (a 10% log fall is a 9.5% price fall).

Today so far

2026-11-04 UTC, as of ≈00:27 UTC (block 9,429,031)

Price, today so far: 0.002231 τ
Volume, today so far: 0.38 τ
Market cap incl. burned, today so far: 7.04K τ
TAO in pool, today so far: 6.01K τ
Emission share, today so far: —not available yet

The day isn’t over yet, so these figures keep changing. They are in no daily total, average or rank.

Subnet Configuration

Pool & Mechanism

AMM Pool

Balancer

Mechanism

dTAO

Access

Registration

Open

Neurons

256/256Competitive

Validators

10/6454 open

Economics

Owner Cut

18.00%

Weights

Disabled

Disabled

1002

1–65535

Timing

Tempo

360~1.2h

Immunity Period

7,200~1.0d

Activity Cutoff

5,000~16.7h

Market & Economics

Market

Market Cap

6,076.2869 τ

FDV

13.05K τ

TVL

12.01K τ

Lifetime Volume

612.30K τ

Holders

1,786

Owner Locked

56,327.5183 ث(2.07% of circulating)Perpetual

14d price

Revenue / Recycle

49.83×

last day · Net positive

Emissions

<0.01%of network emissions

TAO emitted to this subnet

Sent into its pool each day: its share of network emissions

0.2249 τ/day

0.2249 τ per day

Daily distribution

Alpha paid out each day, valued at the pool price

7,200.0000 ث/day

≈ 16.0654 τ·16.0654 τ per day

Miners44.18%

3,181.2615 ث ≈ 7.0984 τ/day

Validators37.82%

2,722.7715 ث ≈ 6.0753 τ/day

Owner18.00%

1,295.9670 ث ≈ 2.8917 τ/day

Stake 1,000 τ here

453.2705 ث/day≈ 1.0114 τ·1.0114 τ per day

From the validator share, before commission

38.17%staker APY

· 30d avg 38.17% · Stable

90d

Pool emits 1.0000 ث/block at 0.002231 τ/ث. Yield varies with stake weight, pool price, and emission rate.

For Miners

44.18% of emission

Slots

256/256Competitive

Burn Cost

0.0005 τ

Est. per Miner

15.9063 ث/epoch≈ 0.0355 τ

Pool / Epoch

159.0631 ث≈ 0.3549 τ

For Validators & Stakers

37.82% of emission

Validator Slots

10/6454 open

Est. per Validator

13.6139 ث/epoch≈ 0.0304 τ

Registration Activity

Neuron registration trends

This Interval

24h: 51 registrations (51 burn · 0 PoW)

Target / Interval

Slots Available

Competitive

256/256

Neurons

256

Development Activity

genomesio/subnet-niomePython

001 contributors6 commits/30dLast commit 13d ago

Top Contributors

jgenome49

What NIOME does

Genome editing research is constrained by the scarcity and cost of large-scale CRISPR datasets. Existing datasets are expensive to generate experimentally, biased toward a small number of gene loci, limited in mutation diversity—particularly for disease-relevant variants like HBB mutations—and insufficient for training robust, generalizable machine learning models for editing outcomes.

A decentralized network of contributors can generate synthetic CRISPR experimental data at arbitrary scale without requiring wet-lab infrastructure. By distributing the data generation task and implementing economic incentives for quality submissions, a network can explore sequence-function space across disease-relevant variants while maintaining biological consistency through computational validation.

NIOMe implements this on Bittensor subnet 55 by coordinating miners who generate CRISPR experimental designs (guide RNA sequences, target positions, mutations, Cas systems) conforming to HBB-focused task specifications.

Validators evaluate each submission through five progressive stages—structural validity, statistical plausibility, biophysical outcome simulation, cross-consistency learning, and distributional fidelity to real CRISPR data—then reward miners in TAO based on submission quality.

Auto-generated from the GitHub repository and may not reflect the latest changes.

About

active

NIOME is a decentralized compute network on Bittensor subnet 55 for generating synthetic CRISPR experiment datasets focused on the HBB (beta-globin) gene locus. Miners generate biologically constrained CRISPR experimental designs, while validators evaluate submissions through a progressive multi-stage validation pipeline that checks structural validity, biological plausibility, biophysical outcomes, cross-consistency, and distributional fidelity to real CRISPR data.

How it works

The NIOME subnet follows a distributed validation architecture. The backend generates CRISPR dataset generation tasks focused on HBB gene locus and provides them to validators. Validators fetch tasks and broadcast them to miners.

Miners generate lists of CRISPR experiments conforming to task specifications (including guide RNA sequences, target positions, mutation types, Cas system choices) and upload datasets to validator-provided cloud storage (S3 or Google Drive) via presigned URLs. Validators evaluate submissions through a progressive 5-stage validation pipeline, from basic structural checks to sophisticated biophysical simulations and distributional fidelity tests. Based on multi-stage evaluation scores, validators assign rewards in TAO to miners.

Incentive mechanism

Validators run a 5-stage validation pipeline: (1) Structural Gate - validates DNA syntax, PAM sequences, guide length, mutation whitelist compliance; (2) Statistical Plausibility - evaluates GC content, spatial consistency, structural realism; (3) Biophysical Simulation - simulates cut probability, repair pathways (HDR/NHEJ), indel distributions; (4) Cross-Consistency - checks learned biological relationships using ML models; (5) Distributional Fidelity - compares synthetic datasets to real CRISPR data distributions. Miners must NOT include predicted efficiency scores, repair outcomes, or derived biological labels - all outcomes are computed exclusively by validators to prevent optimization shortcuts.

The sections above were auto-generated from the GitHub repository and may not reflect the latest changes. View repository (github.com, opens in a new tab, external site)

On-Chain Identitysigned on-chain by subnet owner

NIOME

Theh · Arabic letter · pronounced “theh”

NIOME is a decentralized AI subnet that enables privacy-safe genomic intelligence by replacing real human genomes with high-fidelity synthetic genomic profiles

Owner: 5GeWU…MpDq
Hotkey: 5DJ5f…fYVd
Owner Cut: 18.00%
Contact: [email protected]

Registered: 1y 9mo ago(Jan 14, 2025)
Block: 4,703,386
Slot history: Every subnet in SN55
Neurons: 256/256
Tempo: 360 blocks

Website

URL: https://niome.genomes.io/ (niome.genomes.io, opens in a new tab, external site)
Status: Up200
TLS: Valid
Title: NIOME | Privacy-Safe Synthetic Genomic Data for Pharma Research | Bittensor Subnet
Checked: 2026-11-03 04:04 UTC

Changes (1)

2026-10-13 08:01 UTCUp200NIOME | Privacy-Safe Synthetic Genomic Data for Pharma Research | Bittensor Subnet

Subnet History

SubnetIdentitySet 2026-02-12 16:00 UTC

Block 7,528,845Extrinsic

SubnetIdentitySet 2026-01-29 19:06 UTC

Block 7,429,500Extrinsic

SubnetIdentitySet 2026-01-29 19:06 UTC

Block 7,429,496Extrinsic

SubnetIdentitySet 2025-07-17 18:22 UTC

Block 6,018,508Extrinsic

SubnetIdentitySet 2025-03-11 14:30 UTC

Block 5,105,385Extrinsic

Recent Activity

SubnetIdentitySet Block 7,528,845 Extrinsic2026-02-12 16:00 UTC
SubnetIdentitySet Block 7,429,500 Extrinsic2026-01-29 19:06 UTC
SubnetIdentitySet Block 7,429,496 Extrinsic2026-01-29 19:06 UTC
SubnetIdentitySet Block 6,018,508 Extrinsic2025-07-17 18:22 UTC
SubnetIdentitySet Block 5,105,385 Extrinsic2025-03-11 14:30 UTC

This information was auto-extracted from the GitHub repository and may be incomplete or out of date. Always refer to the subnet's GitHub repository (github.com, opens in a new tab, external site) for the latest instructions.

Hardware Requirements

Miner

GPURequired

RAM16 GB

CPU Cores16

OSUbuntu 22.04 or similar Linux

NetworkPort forwarding required

Not yet verified: Notes

Validator

CPU Cores32

OSUbuntu 22.04 or similar Linux

NetworkHigh uptime and stable networking required

Not yet verified: GPU, RAM, Storage, Notes

Machine-extracted from the subnet's repository docs; may be wrong or out of date. Check the repository before buying or renting hardware. Open the repository (github.com, opens in a new tab, external site) · Extracted 19 Oct 2026

Miner Setup

Clone the NIOME subnet repository

git clone https://github.com/genomesio/subnet-niome.git && cd subnet-niome

Create and activate a Python virtual environment(optional)

python3 -m venv venv && source venv/bin/activate

Install required Python dependencies

python3 -m pip install -r requirements.txt

Install Bittensor CLI tools

python3 -m pip install bittensor-cli

Create a coldkey (primary wallet) for storing TAO

btcli wallet new_coldkey --wallet.name your_coldkey

Create a hotkey (miner identity) linked to the coldkey

btcli wallet new_hotkey --wallet.name your_coldkey --wallet.hotkey your_hotkey

Fund your coldkey wallet with TAO to cover registration fees

Transfer TAO to your coldkey address

btcli subnet register --netuid 55 --wallet.name your_coldkey --wallet.hotkey your_hotkey

Set Python path to include project root

export PYTHONPATH="$PYTHONPATH:$(pwd)"

Start the miner neuron

python neurons/miner.py --netuid 55 --subtensor.network finney --wallet.name your_coldkey --wallet.hotkey your_hotkey --axon.port your_port

Keep miner active and online to receive validator queries(optional)

Use pm2 or tmux to keep miner running in background

Validator Setup

Clone the NIOME subnet repository

git clone https://github.com/genomesio/subnet-niome.git && cd subnet-niome

Create and activate a Python virtual environment(optional)

python3 -m venv venv && source venv/bin/activate

Install required Python dependencies

python3 -m pip install -r requirements.txt

Set up Docker repository and GPG key

sudo apt-get update && sudo apt-get install -y ca-certificates curl gnupg && sudo install -m 0755 -d /etc/apt/keyrings && curl -fsSL https://download.docker.com/linux/ubuntu/gpg | sudo gpg --dearmor -o /etc/apt/keyrings/docker.gpg

Add Docker APT source repository

echo "deb [arch=$(dpkg --print-architecture) signed-by=/etc/apt/keyrings/docker.gpg] https://download.docker.com/linux/ubuntu $(. /etc/os-release && echo $VERSION_CODENAME) stable" | sudo tee /etc/apt/sources.list.d/docker.list > /dev/null

Install Docker packages

sudo apt-get update && sudo apt-get install -y docker-ce docker-ce-cli containerd.io docker-buildx-plugin docker-compose-plugin

Verify Docker installation

docker run --rm hello-world

Configure cloud storage for miner submissions (AWS S3 OR Google Drive)

Copy .env.example to .env and configure AWS S3 or Google Drive credentials

Make entrypoint script executable

chmod +x entrypoint.sh

Run validator setup and initialization script interactively

./entrypoint.sh

No hardware? Back this subnet by staking instead New to mining? Start with the setup guide Validator setup guide

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sudo apt-get update && sudo apt-get install -y ca-certificates curl gnupg && sudo install -m 0755 -d /etc/apt/keyrings && curl -fsSL https://download.docker.com/linux/ubuntu/gpg | sudo gpg --dearmor -o /etc/apt/keyrings/docker.gpg

echo "deb [arch=$(dpkg --print-architecture) signed-by=/etc/apt/keyrings/docker.gpg] https://download.docker.com/linux/ubuntu $(. /etc/os-release && echo $VERSION_CODENAME) stable" | sudo tee /etc/apt/sources.list.d/docker.list > /dev/null

What moved the price

Overview

Today so far

Subnet Configuration

Market & Economics

For Miners

For Validators & Stakers

Registration Activity

Development Activity

What NIOME does

About

Website

Subnet History

Recent Activity

Participate

Hardware Requirements

Miner Setup

Validator Setup

What moved the price

Today so far

Subnet Configuration

Market & Economics

For Miners

For Validators & Stakers

What NIOME does

About

Website

Subnet History

Hardware Requirements

Miner Setup

Validator Setup